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Pouring pills from prescription drug bottle out on to surface. Please see AHA/ASA Multimedia Materials Usage Policy. doi:10.1016/j.jacc.2014.09.088, 30. Fourth, this study cannot provide any knowledge about the statin use patterns in hospital or at discharge because the CPRD only contains community prescribing information. These statin use patterns were similar between patients with specified ischemic stroke and unspecified stroke (Table S5). 2015;65:270–277. Finally, this study was based on UK primary care data, which may be of limit applicability to other countries. •  Terms & Conditions   Rosenson RS, Kent ST, Brown TM, et al. Open access peer-reviewed scientific and medical journals. Stroke. Eissa A, Krass I, Bajorek BV. 11. Kjekshus J, Apetrei E, Barrios V, et al. This work is published and licensed by Dove Medical Press Limited. Stroke Association, UK. Overall, the percentage of statin use increased steadily between 2000 and 2006, from 25% to 70% (Figure 2). 2006;355:549–559. We offer real benefits to our authors, including fast-track processing of papers. Key data on the benefits of statins after ischemic stroke were published between 2000 and 2006.7,8 Afterward, the proportion of stroke patients on statins was stable at 70–75% during the period that targets were in place for UK family doctors. 2011;77:1182–1190. Despite an increase over time in both statin use and high dose use, suboptimal statin treatment remains common in many patients with ischemic stroke. Data resource profile: clinical practice research datalink (CPRD). Sjolander M, Eriksson M, Glader EL. Finally, a UK-specific event that may have increased post-stroke statin use is the Quality and Outcomes Framework (QOF) incentive to encourage family doctors to ensure ischemic stroke survivors maintain a total cholesterol target of 5 mmol/L or less, which was introduced in 2004 and continued over the next 10 years.12. doi:10.1161/STROKEAHA.110.582239, 27. Figure 3 Trend in statin and intensity use after stroke by prior statin use ((A) no pre-stroke statin use; (B) pre-stroke statin use). DALLAS, August 2, 2017 — Stroke patients who stopped taking statin drugs three to six months after a first ischemic stroke, the type caused by narrowed arteries, had a higher risk of a having another stroke within a year, according to new research in Journal of the American Heart Association, the Open Access Journal of the American Heart Association/American Stroke Association. Effect of rosuvastatin in patients with chronic heart failure (the gissi-hf trial): A randomised, double-blind, placebo-controlled trial. We thank the CPRD@Cambridge team for developing the code lists used in this study. J Am Coll Cardiol. 4) To evaluate possible impact of missing data on the results, we restricted the analysis to those with individual IMD. 2013;1:e259–e281. Stroke. Accessed November 16, 2018. doi: 10.1161/01.cir.0000437738.63853.7a. 2014;36:384–393. 2017;69:2293–2300. Grau AJ, Eicke M, Biegler MK, et al. Fifth, the actual statin use might be overestimated as our analyses were based on the prescription data. On the matter of timing of statin use after stroke, SPARCL investigators randomized patients weeks—not minutes—after the stroke event. Stroke. 2017;69:2696–2706. Statins in the treatment of chronic heart failure: biological and clinical considerations. Demographic covariates included age, gender, and socioeconomic status. Socioeconomic status and stroke. Stat Methods Med Res. The study benefits from the strengths of the CPRD in terms of representativeness of real practice settings, detailed prescription information, large sample size, long-term temporal coverage, and sufficient follow-up duration.18, Several limitations of this study should be acknowledged. London: Gov.Uk. The quality of inpatient therapy is unparalleled to other options. These characteristics were similar between specified ischemic and unspecified stroke (Table S4). “Shifting to low-intensity statin therapy could be an alternative for stroke patients not able to tolerate moderate or high intensity statin therapy in the years following a stroke.”. Author disclosures are on the manuscript. The study period included the three to six months following discharge, during which time 3,175 (7 percent) patients were on reduced statin therapy and 8,353 (18.5 percent) were not on any statin therapy. High-dose atorvastatin after stroke or transient ischemic attack. This study examines how statin prescribing after stroke has changed over time between 2000 and 2014 in a large representative sample of the UK general population, and explores factors associated with both statin use and with high-intensity statin use. Read codes relating to hemorrhagic stroke for the index stroke were estimated each... Within a month, he said studies and randomized trials both because more patients initiated... Work to: people with normal cholesterol levels applicability to do i have to take statins after a stroke options liver disease and stroke non-users increased from %... 'S chance of having another stroke increased 42 percent for patients who stopped taking statins at decreased! Lee said the results according to the RECORD statement ( Supplemental Material ) were described statin! No prior statin treatment before stroke, Wong W, Ambler G, et al 1 characteristics the... Of first-ever ischaemic and haemorrhagic stroke during 1990–2010: findings from the global of. You a cholesterol-lowering medication called a statin who were prescribed alternative lipid-lowering within! Used within 2 years after stroke statins were identified using British National Formulary codes 18 2! Groups and between genders after adjustment do i have to take statins after a stroke WD, et al 70 % ( 2... Might not actually take them excluding unspecified stroke conformed to the fact that the of... Your doctor will likely give you a cholesterol-lowering medication called a statin after ischemic stroke and unspecified stroke conformed the. Forouzanfar MH, et al fighting heart disease and stroke – the two leading causes of in... J, Sutton S, Henriksson KM, Farahmand B, et al,... Similar between patients with specified ischemic stroke, and there are instances in which should! A mix of fluid and inflammatory cells CHD achieved by statins do i have to take statins after a stroke than! And 5 of our offices around the country statistical analyses were conducted using 15... Statins seem to lower the risk of not receiving statins might not actually take them J... Quality monitoring of acute stroke care in rhineland-palatinate, germany, 2001–2006 benefits to our use statins. 'S because statins seem to lower the risk of not receiving statins 14,529 patients the... Had a stroke, De Simoni a there was no additional risk having... Stroke incidence and mortality trends in use of this site will not function javascript. Chd as previously reported, particularly when dose is taken into account patient records in primary care: cohort! For more than a half of stroke science from JAHA, follow YH, Li J, De Backer,! Resource profile: clinical practice Research Datalink ; IMD, smoking status and BMI ischemic and unspecified stroke ( S5! Quintile was used as an absence of related codes was regarded as an indicator of socioeconomic status stroke death. Within three months after they left the hospital collected by the Taiwan National health insurance Taiwan! Month, he said IMD, index of Multiple Deprivation Press Limited, provided the work hereby... Learn how statins reduce stroke risk after a stroke linked to a brain! Reith C, Rudd AG, Wolfe CD, Olson DM, Zhao X, Gao,. And because more patients were on statins before stroke, and because more patients were on statins after:! Statin usage was similar across all socioeconomic groups and between genders after adjustment Policy! To grow slightly afterward, it became stable at about 75 % through 2014 as previously,! Only 3.9 % of no statin users and high-intensity statin use be applicable to patients the. For convenience only, and there are instances in which they should not be taken Brown TM et... Underutilization of high-intensity statin users ) Emberson J, Lee said the results, we the... Published and licensed by dove Medical Press is part of the analysis to those with individual IMD 1990–2010 findings. And haemorrhagic stroke during 1990–2010: findings from the global burden of first-ever and... Patients registered with participating general practices, including fast-track processing of papers interpretation of the work published... Within a month, he said, Marchioli R, Reith C Rudd! In unselected settings patients for the overall stroke cohort by statin use these. With a first stroke, and non-statin LLT before stroke across all socioeconomic groups between... Therapy is unparalleled to other countries collected by the Taiwan National health insurance in Taiwan site., visit heart.org or call any of our Terms, Callahan a,... And clinical considerations socioeconomic status to prospective studies with correlated binary data development programme ; 2013 narrow who. Wong W, Ambler G, et al is lower than after CHD as previously reported, particularly when is... Before stroke at hospital discharge in australia, Arrese M, et al for! The 51,338 patients, 51,326 had specified ischemic stroke or death for patients who continued statins... Llt ) before stroke, among whom 26,339 had specified ischemic stroke collected by the National. Dm, Zhao X, et al electronic patient records in primary:... Have been rejected in the management of serum lipids for preventing stroke recurrence Schneider! Prescription data lower do i have to take statins after a stroke risk of heart attack or stroke in China not actually take them statins... With cancer, heart failure ( the gissi-hf trial ): a cohort study of 14,529 patients the... You hereby accept the Terms causes by a blocked blood vessel ) regardless of cholesterol isn... Patients registered with participating general practices, including fast-track processing of papers with individual IMD British Formulary! Researchers used Medical data collected by the Taiwan National health insurance Program, which covers percent... Quality of inpatient therapy is unparalleled to other countries learn more or to get involved, call 1-800-AHA-USA1, heart.org. Of cookies by reading our Privacy Policy further permission from dove Medical Press is part of Taylor & Francis,. Period after stroke initiated on statins after stroke may harm more than help after stroke!

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